Dr. Enrique Alejandro Sánchez Pastor

 

 

 

 

• Contacto:

 

 

•    Participación del sistema endocannabinoide en enfermedades cardiovasculares. CONACYT.

•    Mantenimiento preventivo y/o correctivo de equipos de áreas de uso común para el desarrollo de las líneas de investigación del Centro Universitario de Investigaciones Biomédicas de la Universidad de Colima. CONACYT.
•    Mecanismos de acción de los canabinoides en el tono vascular. CONACYT.

•    Modulación del tono vascular por el sistema endocanabinoide en arteriosclerosis inducida en ratas. FRABA.
•    Mecanismos de acción de los efectos de los canabinoides en músculo liso. FRABA.

•    Papel de los receptores a canabinoides en la relajación inducida por canabinoides en músculo liso. FRABA.
•    Mecanismos de acción de los efectos de los canabinoides en músculo liso. PRODEP.

 

 

•    Hu D, Huang Y, Rangel-Sandoval C, Sánchez-Pastor E, Onetti CG, Ferrer-Villada T, Jiang MN, Hasdemir C, Akin I, Zhou XB, El-Battrawy I, Cui M, Romano J, Pinheiro M, Acuña-Ochoa JG, Chen L, Zhuang LN, Hao GL, Zhan LY, Jiang H, Antzelevitch C, Barajas-Martínez H. Biophysical Characterization of a Novel KCNJ8 Rare Variant Linked With Inherited and Acquired J Wave Syndrome. JACC Clin Electrophysiol. 2026 Apr 16:S2405-500X(26)00135-0. doi: 10.1016/j.jacep.2026.02.005.

•    Avalos-Moreno DA, Cuevas-Carbonell SG, Ramírez-Vargas ME, Castro-Sánchez L, Virgen-Ortiz A, Sánchez-Pastor E, Góngora-Alfaro JL, Navarro-Polanco RA, Moreno-Galindo EG, Alamilla J. Combined administration of intracerebroventricular CB1 agonist ACEA and systemic TRPV1 agonist capsaicin induces synergistic antidepressant-like effects in rats. Behav Brain Res. 2026 Apr 12;503:116050. doi: 10.1016/j.bbr.2026.116050.

•    Álvarez-Valadez MDR, Rodríguez-Hernández A, Andrade-Urzúa F, Limón-Miranda S, Ceballos-Gutiérrez A, Velasco-Gutiérrez JA, Gamboa-Domínguez A, Virgen-Ortiz A, Sánchez-Pastor E. Novel Murine Model of Atherosclerosis Progression Induced by a Modified Paigen Diet. Biomedicines. 2025 Nov 8;13(11):2736. doi: 10.3390/biomedicines13112736.

•   Prado-Celis LP, Zamora-Cárdenas R, Alamilla J, Sánchez-Pastor EA, Ferrer T, Moreno-Galindo EG, Navarro-Polanco RA. Nucleolar sequestration of cannabinoid type-2 receptors in triple-negative breast cancer cells. PLoS One. 2025 May 13;20(5):e0323554. doi: 10.1371/journal.pone.0323554.

•   Molina-Pelayo FA, Zarate-Lopez D, García-Carrillo R, Rodríguez-Beas C, Íñiguez-Palomares R, Rodríguez-Mejía JL, Soto-Guzmán A, Velasco-Loyden G, Sierra-Martínez M, Virgen-Ortiz A, Sánchez-Pastor E, Magaña-Vergara NE, Baltiérrez-Hoyos R, Alamilla J, Chagoya de Sánchez V, Dagnino-Acosta A, Chávez E, Castro-Sánchez L. miRNAs-Set of Plasmatic Extracellular Vesicles as Novel Biomarkers for Hepatocellular Carcinoma Diagnosis Across Tumor Stage and Etiologies. Int J Mol Sci. 2025 Mar 12;26(6):2563. doi: 10.3390/ijms26062563.

•   Osuna-Lopez F, Herrera-Zamora JM, Reyes-Méndez ME, Aguilar-Roblero RA, Sánchez-Pastor EA, Navarro-Polanco RA, Moreno-Galindo EG, Alamilla J. Age-, region-, and day/night-related variation of the chloride reversal potential in the rat suprachiasmatic nucleus. J Neurosci Res. 2024 Aug;102(8):e25373. https://doi.org/10.1002/jnr.25373.

 

•   Herrera-Zamora JM, Osuna-Lopez F, Reyes-Méndez ME, Valadez-Lemus RE, Sánchez-Pastor EA, Navarro-Polanco RA, Moreno-Galindo EG, Alamilla J. Increased glutamatergic neurotransmission between the retinohypothalamic tract and the suprachiasmatic nucleus of old mice. Journal of Neuroscience Research. 2024, 102(4), e25331. https://doi.org/10.1002/jnr.25331

 

•    Reyes-Méndez ME, Herrera-Zamora JM, Osuna-Lopez F, Aguilar-Martínez IS, Góngora-Alfaro JL, Navarro-Polanco RA, Sánchez-Pastor E, Moreno-Galindo EG, Alamilla J. Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus. Synapse. 2023. 77(1) e22250. https://doi.org/10.1002/syn.22250.

 

•   López, M., Quintero-Macías, L., Huerta, M., Rodríguez-Hernández, A., Melnikov, V., Cárdenas, Y., Bricio-Barrios, J.A., Sánchez-Pastor, E., Gamboa-Domínguez, A., Leal, C., Trujillo, X., Ríos-Silva, M. Capsaicin Decreases Kidney Iron Deposits and Increases Hepcidin Levels in Diabetic Rats with Iron Overload: A Preliminary Study. Molecules. 2022. 27(22):7764. https://doi.org/110.3390/molecules27227764.

 

•    Díaz-Reval, M.I., Cárdenas, Y., Huerta, M., Trujillo, X., Sánchez-Pastor E.A., González-Trujano, M.E., Virgen-Ortíz, A. and Pérez-Hernández, M.G. Activation of Peripheral Cannabinoid Receptors Synergizes the Effect of Systemic Ibuprofen in a Pain Model in Rat. Pharmaceuticals (Basel). 2022. 15(8):910. ISSN 1424-8247. https://doi.org/10.3390/ph15080910

•    Ceballos-Gutiérrez, A., Rodríguez-Hernández, A., Álvarez-Valadez, M.R., Limón-Miranda, S., Andrade, F., Figueroa-Gutiérrez, A., Díaz-Reval, I., Apolinar-Iribe A., Castro-Sánchez, L., Alamilla, J., Sánchez-Pastor, E. and Virgen-Ortiz, A. ZnO Nanoparticles Induce Dyslipidemia and Atherosclerotic Lesions Leading to Changes in Vascular Contractility and Cannabinoid Receptors Expression as Well as Increased Blood Pressure. Nanomaterials. 2021. 11:2319. ISSN 2079-4991. https://doi.org/10.3390/nano11092319

•   Sánchez-Pastor, E., Trujillo, X., Ramos-Flores, C., Ríos-Silva, M., Andrade, F., Cárdenas, Y., Castro, E., Urzúa, Z., Newton-Sánchez, O and Huerta, M. Type 2 Diabetes Alters Vascular Cannabinoid Receptor 1 Expression, Phosphorylation Status, and Vasorelaxation in Rat Aorta. Molecules. 2020. 25:4948. ISSN 1420-3049. https://doi.org/10.3390/molecules25214948

•    Virgen-Ortiz, A., Apolinar-Iribe A., Díaz-Reval, I., Parra-Delgado, H., Limón-Miranda, S., Sánchez-Pastor, E., Castro-Sánchez, L., Jesús Castillo S., Dagnino-Acosta, A., Bonales-Alatorre, E. and Rodríguez-Hernández, A. Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats. Nanomaterials. 2020. 10:2005. ISSN 2079-4991. https://doi.org/10.3390/nano10102005

•    Andrade, F., Rangel-Sandoval, C., Rodríguez-Hernández, A., López-Dyck, E., Elizalde, A., Virgen-Ortiz, A., Bonales-Alatorre, E., Valencia-Cruz, G. and Sánchez-Pastor, E. Capsaicin Causes Vasorelaxation of Rat Aorta through Blocking of L-type Ca2+ Channels and Activation of CB1 Receptors. Molecules. 2020. 25:3957. ISSN 1420-3049. https://doi.org/10.3390/molecules25173957