Profesor e Investigador

 

 

•    Profesor-Investigador de Tiempo Completo Asociado “C”
•    Doctor en Ciencias Fisiológicas
•    Miembro del Sistema Nacional de Investigadores Nivel 1 2022-2024 
•    Perfil deseable SES-SEP 2022-2025
•    Línea de Generación y Aplicación del Conocimiento: Biomedicina

 

•    Participación del sistema endocannabinoide en enfermedades cardiovasculares. 

En este proyecto se estudian los mecanismos moleculares involucrados en la generación de enfermedades cardiovasculares y la participación del sistema endocannabinoide. Estos estudios se realizan  empleando modelos animales de aterosclerosis, hipertensión, isquemia cardiaca y diabetes.
•    Académico responsable: Dr. Enrique Alejandro Sánchez Pastor
•    Fuente de financiamiento: CONACYT
•    Datos de contacto: (Tel: 3121544555 Ext 551. Email: espastor@ucol.mx

 

 

 

•    Díaz-Reval, M.I., Cárdenas, Y., Huerta, M., Trujillo, X., Sánchez-Pastor E.A., González-Trujano, M.E., Virgen-Ortíz, A. and Pérez-Hernández, M.G. Activation of Peripheral Cannabinoid Receptors Synergizes the Effect of Systemic Ibuprofen in a Pain Model in Rat. Pharmaceuticals (Basel). 2022. 15(8):910. ISSN 1424-8247. https://doi.org/10.3390/ph15080910

•    Ceballos-Gutiérrez, A., Rodríguez-Hernández, A., Álvarez-Valadez, M.R., Limón-Miranda, S., Andrade, F., Figueroa-Gutiérrez, A., Díaz-Reval, I., Apolinar-Iribe A., Castro-Sánchez, L., Alamilla, J., Sánchez-Pastor, E. and Virgen-Ortiz, A. ZnO Nanoparticles Induce Dyslipidemia and Atherosclerotic Lesions Leading to Changes in Vascular Contractility and Cannabinoid Receptors Expression as Well as Increased Blood Pressure. Nanomaterials. 2021. 11:2319. ISSN 2079-4991. https://doi.org/10.3390/nano11092319

•    Sánchez-Pastor, E., Trujillo, X., Ramos-Flores, C., Ríos-Silva, M., Andrade, F., Cárdenas, Y., Castro, E., Urzúa, Z., Newton-Sánchez, O and Huerta, M. Type 2 Diabetes Alters Vascular Cannabinoid Receptor 1 Expression, Phosphorylation Status, and Vasorelaxation in Rat Aorta. Molecules. 2020. 25:4948. ISSN 1420-3049. https://doi.org/10.3390/molecules25214948

•    Virgen-Ortiz, A., Apolinar-Iribe A., Díaz-Reval, I., Parra-Delgado, H., Limón-Miranda, S., Sánchez-Pastor, E., Castro-Sánchez, L., Jesús Castillo S., Dagnino-Acosta, A., Bonales-Alatorre, E. and Rodríguez-Hernández, A. Zinc Oxide Nanoparticles Induce an Adverse Effect on Blood Glucose Levels Depending On the Dose and Route of Administration in Healthy and Diabetic Rats. Nanomaterials. 2020. 10:2005. ISSN 2079-4991. https://doi.org/10.3390/nano10102005

•    Andrade, F., Rangel-Sandoval, C., Rodríguez-Hernández, A., López-Dyck, E., Elizalde, A., Virgen-Ortiz, A., Bonales-Alatorre, E., Valencia-Cruz, G. and Sánchez-Pastor, E. Capsaicin Causes Vasorelaxation of Rat Aorta through Blocking of L-type Ca2+ Channels and Activation of CB1 Receptors. Molecules. 2020. 25:3957. ISSN 1420-3049. https://doi.org/10.3390/molecules25173957

•    Virgen-Ortiz A, Limón-Miranda S, Salazar-Enríquez DG, Melnikov V, Sánchez-Pastor EA, Castro-Rodríguez EM. Matrix Metalloproteinases System and Types of Fibrosis in Rat Heart during Late Pregnancy and Postpartum. Medicina (Kaunas). 2019. 55:199. ISSN 1648-9144. https://doi.org/10.3390/medicina55050199

•    Herrera-Zamora JM, Castro-Sánchez LA, Reyes-Mendez M, Aguilar-Martinez I, Osuna-López F, Moreno-Galindo EG, Navarro-Polanco RA, Aguilar-Roblero RA, Sánchez-Pastor E, Alamilla J. Development-Dependent Changes in the NR2 Subtype of the N-Methyl-D-Aspartate Receptor in the Suprachiasmatic Nucleus of the Rat. J Biol Rhythms. 2019. 34:39-50. ISSN 1552-4531. https://doi.org/10.1177/0748730418824198