Dr. Javier Francisco Alamilla González

Patente:

“Uso combinado de un agonista trpv 1 y un agente terapéutico antidepresivo para el tratamiento de los síntomas de la depresión” con número de expediente MX/a/2019/009958.

Publicaciones Recientes

• Avalos-Moreno DA, Cuevas-Carbonell SG, Ramírez-Vargas ME, Castro-Sánchez L, Virgen-Ortiz A, Sánchez-Pastor E, Góngora-Alfaro JL, Navarro-Polanco RA, Moreno-Galindo EG, Alamilla J. Combined administration of intracerebroventricular CB1 agonist ACEA and systemic TRPV1 agonist capsaicin induces synergistic antidepressant-like effects in rats. Behav Brain Res. 2026 Apr 12;503:116050. doi: 10.1016/j.bbr.2026.116050.
• Zamora-Cárdenas R, López-Serrano AL, Ferrer T, Alamilla J, Rodríguez-Menchaca AA, Moreno-Galindo EG, Navarro-Polanco RA. The progression of triple-negative breast cancer is linked to a gradual decrease of the BK channel in the plasma membrane and an increase in intracellular structures. Pflugers Arch. 2026 Jan 22;478(2):19. doi: 10.1007/s00424-025-03133-0.
• Aguilar-Martínez IS, Góngora-Alfaro JL, Navarro-Polanco RA, Castro-Sánchez L, Moreno-Galindo EG, Alamilla J. Synergistic effects of capsaicin and ketamine on the depression-like behaviors of animals subjected to the chronic unpredictable mild stress protocol. Physiol Behav. 2026 Jan 1;303:115122. doi: 10.1016/j.physbeh.2025.115122.
• Prado-Celis LP, Zamora-Cárdenas R, Alamilla J, Sánchez-Pastor EA, Ferrer T, Moreno-Galindo EG, Navarro-Polanco RA. Nucleolar sequestration of cannabinoid type-2 receptors in triple-negative breast cancer cells. PLoS One. 2025 May 13;20(5):e0323554. doi: 10.1371/journal.pone.0323554.
• Molina-Pelayo FA, Zarate-Lopez D, García-Carrillo R, Rodríguez-Beas C, Íñiguez-Palomares R, Rodríguez-Mejía JL, Soto-Guzmán A, Velasco-Loyden G, Sierra-Martínez M, Virgen-Ortiz A, Sánchez-Pastor E, Magaña-Vergara NE, Baltiérrez-Hoyos R, Alamilla J, Chagoya de Sánchez V, Dagnino-Acosta A, Chávez E, Castro-Sánchez L. miRNAs-Set of Plasmatic Extracellular Vesicles as Novel Biomarkers for Hepatocellular Carcinoma Diagnosis Across Tumor Stage and Etiologies. Int J Mol Sci. 2025 Mar 12;26(6):2563. doi: 10.3390/ijms26062563.
• Valadez-Lemus RE, Góngora-Alfaro JL, Jiménez-Vargas JM, Alamilla J, Mendoza-Muñoz N. Nanoencapsulation of amitriptyline enhances the potency of antidepressant-like effects and exhibits anxiolytic-like effects in Wistar rats. PLoS One. 2025 Feb 28;20(2):e0316389. doi: 10.1371/journal.pone.0316389.
• Dobrovinskaya O, Alamilla J, Olivas-Aguirre M. Impact of Modern Lifestyle on Circadian Health and Its Contribution to Adipogenesis and Cancer Risk. Cancers (Basel). 2024 Nov 1;16(21):3706. doi: 10.3390/cancers16213706.
• Osuna-Lopez F, Herrera-Zamora JM, Reyes-Méndez ME, Aguilar-Roblero RA, Sánchez-Pastor EA, Navarro-Polanco RA, Moreno-Galindo EG, Alamilla J. Age-, region-, and day/night-related variation of the chloride reversal potential in the rat suprachiasmatic nucleus. J Neurosci Res. 2024 Aug;102(8):e25373.
• Herrera-Zamora JM, Osuna-Lopez F, Reyes-Méndez ME, Valadez-Lemus RE, Sánchez-Pastor EA, Navarro-Polanco RA, Moreno-Galindo EG, Alamilla J. Increased glutamatergic neurotransmission between the retinohypothalamic tract and the suprachiasmatic nucleus of old mice. J Neurosci Res. 2024 Apr;102(4):e25331
• Reyes-Méndez ME, Herrera-Zamora JM, Osuna-Lopez F, Aguilar-Martínez IS, Góngora-Alfaro JL, Navarro-Polanco RA, Sánchez-Pastor E, Moreno-Galindo EG, Alamilla J. Developmental light deprivation transiently reduces the expression of vGluT2 and GluN2B in the rat ventral suprachiasmatic nucleus. Synapse. 2023 Jan;77(1):e22250. doi: 10.1002/syn.22250. Epub 2022 Sep 22. PMID: 36085433.
• Cuevas-Carbonell SG, Vásquez-Celaya L, García-López D, Granados-Patrón D, García-Miss MDR, Álvarez-Cervera FJ, Mut-Martín M, Parra I, Mendieta L, Salgado H, Alamilla J, Cruz-Bojórquez R, Ávila-Escalante ML, Aranda-González II, Góngora-Alfaro JL. Chronic Treatment with the Probiotics Lacticaseibacillus rhamnosus GG and Bifidobacterium lactis BB12 Attenuates Motor Impairment, Striatal Microglial Activation, and Dopaminergic Loss in Rats with 6-Hydroxydopamine-induced Hemiparkinsonism. Neuroscience. 2022 Dec 15;507:79-98.
• López-Serrano AL, Zamora-Cárdenas R, Aréchiga-Figueroa IA, Salazar-Fajardo PD, Ferrer T, Alamilla J, Sánchez-Chapula JA, Navarro-Polanco RA, Moreno-Galindo EG. Differential voltage-dependent modulation of the ACh-gated K+ current by adenosine and acetylcholine. PLoS One. 2022 Jan 14;17(1):e0261960.
• Osuna-Lopez F, Reyes-Mendez ME, Herrera-Zamora JM, Gongora-Alfaro JL, Moreno-Galindo EG, Alamilla J. GABA Neurotransmission of the Suprachiasmatic Nucleus Is Modified During Rat Postnatal Development. J Biol Rhythms. 2021 Dec;36(6):567-574.
• Ceballos-Gutiérrez A, Rodríguez-Hernández A, Álvarez-Valadez MDR, Limón-Miranda S, Andrade F, Figueroa-Gutiérrez A, Díaz-Reval I, Apolinar-Iribe A, Castro-Sánchez L, Alamilla J, Sánchez-Pastor E, Virgen-Ortiz A. ZnO Nanoparticles Induce Dyslipidemia and Atherosclerotic Lesions Leading to Changes in Vascular Contractility and Cannabinoid Receptors Expression as Well as Increased Blood Pressure. Nanomaterials (Basel). 2021 Sep 7;11(9):2319.
• Alamilla J, Jiménez-Vargas JM, Galván-Hernández AR, Reyes-Méndez ME, Bermúdez-Gúzman MJ, Restano-Cassulini R, Olamendi-Portugal T, Zamudio FZ, Possani LD, Valdez-Velázquez LL. Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus. Toxicon. 2021 Jul 15;197:114-125.
• Reyes-Mendez ME, Herrera-Zamora JM, Osuna-López F, Navarro-Polanco RA, Mendoza-Muñoz N, Góngora-Alfaro JL, Moreno-Galindo EG, Alamilla J. Light stimulation during postnatal development is not determinant for glutamatergic neurotransmission from the retinohypothalamic tract to the suprachiasmatic nucleus in rats. Eur J Neurosci. 2021 Jul;54(2):4497-4513.
• Alamilla J, Ramiro-Cortés Y, Mejía-López A, Chavez JL, Rivera DO, Felipe V, Aguilar-Roblero R. Altered Light Sensitivity of Circadian Clock in Shank3+/- Mouse. Front Neurosci. 2021 Feb 18;15:604165.
• Parra-Paz VG, Calderón-Sauri A, Granados-Patrón D, Cuevas-Carbonell SG, García-López D, Dawn-Ojeda A, Mut-Martín M, Olivera-Castillo L, Álvarez-Cervera FJ, Salgado H, Alamilla J, García-Miss MDR, Vásquez-Celaya L, Aranda-González II, Góngora-Alfaro JL. Chronic feeding with 3% dried raw blueberries (V. corymbosum) reduces apomorphine-induced rotations and striatal dopaminergic loss in hemiparkinsonian rats. Food Res Int. 2021 Feb;140:110066.
• Aguilar-Martinez IS, Reyes-Mendez ME, Herrera-Zamora JM, Osuna-Lopez F, Virgen-Ortiz A, Mendoza-Munoz N, Gongora-Alfaro JL, Moreno-Galindo EG, Alamilla J. Synergistic antidepressant-like effect of capsaicin and citalopram reduces the side effects of citalopram on anxiety and working memory in rats. Psychopharmacology (Berl). 2020 Jul;237(7):2173-2185.
• Reyes-Mendez ME, Osuna-López F, Herrera-Zamora JM, Navarro-Polanco RA, Moreno-Galindo EG, Alamilla J. Functional Pre- and Postsynaptic Changes between the Retinohypothalamic Tract and Suprachiasmatic Nucleus during Rat Postnatal Development. J Biol Rhythms. 2020 Feb;35(1):28-44.
• Herrera-Zamora JM, Castro-Sánchez LA, Reyes-Mendez M, Aguilar-Martinez I, Osuna-López F, Moreno-Galindo EG, Navarro-Polanco RA, Aguilar-Roblero RA, Sánchez-Pastor E, Alamilla J. Development-Dependent Changes in the NR2 Subtype of the N-Methyl-D-Aspartate Receptor in the Suprachiasmatic Nucleus of the Rat. J Biol Rhythms. 2019 Feb;34(1):39-50.