Dr. Miguel Olivas Aguirre

Líneas de investigación

1. Fisiopatología de leucemias.
2. Mitocondria como blanco antileucémico.
3. Microambiente adiposo en el desarrollo de la leucemia.
4. Señalización por calcio en leucemias.
5. Mecanismos de optimización de la actividad citotóxica de células NK.

Proyectos científicos financiados vigentes

Ciencia Básica y de Frontera 2025 (CBF-2025-I) de la SECIHTI, con un financiamiento de $1,250,000.00 MXN y vigencia de 2025 a 2028, titulado: “Rol del microambiente adiposo en el mantenimiento y protección de la leucemia linfoblástica aguda”.

Publicaciones recientes:

1. Torres-López L, Olivas-Aguirre M, Chávez-Gutiérrez A, Dobrovinskaya O. Pharmacological Modulation of Autophagy Can Sensitize Acute Lymphoblastic Leukemia Cell Lines to Dexamethasone. Cancers (Basel). 2026 Feb 28;18(5):775. doi: 10.3390/cancers18050775.
2. Torres-López L, Olivas-Aguirre M, Castellanos-Martínez R, Jiménez-Camacho KE, Pelayo R, Dobrovinskaya O, Schnoor M, Pottosin I. Voltage-dependent Kv1.3 potassium channels in the plasma membrane of acute lymphoblastic leukemic B-cells are non-conductive. Biochem Biophys Res Commun. 2025 Nov 1;787:152771. doi: 10.1016/j.bbrc.2025.152771.
3. Pottosin I, Villatoro-Gómez K, Olivas-Aguirre M, Schnoor M, Dobrovinskaya O. Ion channels in NK cells: Signaling and functions. J Leukoc Biol. 2025 Oct 1;117(10):qiaf127. doi: 10.1093/jleuko/qiaf127.Dobrovinskaya O, Alamilla J, Olivas-Aguirre M. Impact of Modern Lifestyle on Circadian Health and Its Contribution to Adipogenesis and Cancer Risk. Cancers (Basel). 2024 Nov 1;16(21):3706. doi: 10.3390/cancers16213706.
4. Olivas-Aguirre, M., Gutiérrez-Iñiguez, C., Pottosin, I., & Dobrovinskaya, O. (2024). Molecular Targets for Cannabinoids in Natural Killer Cells: Do They Modulate the Antitumor Activity? Receptors, 3(2), 122-144.
5. Olivas-Aguirre, M., Cruz-Aguilar, L. H., Pottosin, I., & Dobrovinskaya, O. (2023). Reduction of Ca2+ Entry by a Specific Block of KCa3.1 Channels Optimizes Cytotoxic Activity of NK Cells against T-ALL Jurkat Cells. Cells, 12(16), 2065.
6. Pottosin, I., Olivas-Aguirre, M., & Dobrovinskaya, O. (2023). In vitro simulation of the acute lymphoblastic leukemia niche: a critical view on the optimal approximation for drug testing. Journal of Leukocyte Biology, 114(1), 21-41.
7. Olivas-Aguirre, M., Pérez-Chávez, J., Torres-López, L., Hernández-Cruz, A., et al. (2023). Dexamethasone-induced fatty acid oxidation and autophagy/mitophagy are essential for T-ALL glucocorticoid resistance. Cancers, 15(2), 445.
8. Olivas-Aguirre, M., Torres-López, L., Villatoro-Gómez, K., Perez-Tapia, S. M., et al. (2022). Cannabidiol on the Path from the Lab to the Cancer Patient: Opportunities and Challenges. Pharmaceuticals, 15(3), 366.
9. Torres-López, L., Olivas-Aguirre, M., Villatoro-Gómez, K., & Dobrovinskaya, O. (2022). The G-protein–coupled estrogen receptor agonist G-1 inhibits proliferation and causes apoptosis in leukemia cell lines of T lineage. Frontiers in Cell and Developmental Biology, 10, 811479.
10. Olivas-Aguirre, M., Torres-López, L., Gómez-Sandoval, Z., Villatoro-Gómez, K., et al. (2021). Tamoxifen Sensitizes Acute Lymphoblastic Leukemia Cells to Cannabidiol by Targeting Cyclophilin-D and Altering Mitochondrial Ca2+ Homeostasis. International Journal of Molecular Sciences, 22(16), 8688.
11. Olivas-Aguirre, M., Torres-López, L., Pottosin, I., & Dobrovinskaya, O. (2021). Overcoming glucocorticoid resistance in acute lymphoblastic leukemia: repurposed drugs can improve the protocol. Frontiers in Oncology, 11, 617937.
12. Pottosin, I., Olivas-Aguirre, M., Dobrovinskaya, O., Zepeda-Jazo, I., & Shabala, S. (2021). Modulation of ion transport across plant membranes by polyamines: understanding specific modes of action under stress. Frontiers in Plant Science, 11, 616077.
13. Olivas-Aguirre, M., Torres-López, L., Pottosin, I., & Dobrovinskaya, O. (2020). Phenolic compounds cannabidiol, curcumin and quercetin cause mitochondrial dysfunction and suppress acute lymphoblastic leukemia cells. International Journal of Molecular Sciences, 22(1), 204.
14. Olivas-Aguirre, M., Torres-López, L., Valle-Reyes, J. S., Hernández-Cruz, A., et al. (2019). Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia. Cell Death & Disease, 10(10), 779.
15. Olivas-Aguirre, M., Pottosin, I., & Dobrovinskaya, O. (2019). Mitochondria as emerging targets for therapies against T cell acute lymphoblastic leukemia. Journal of Leukocyte Biology, 105(5), 935-946.

Sitios de Interés: 

• Google Scholar
• ResearchGate